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Katherine Y. King MD PhD is an Associate Professor of Pediatric Infectious Diseases at Baylor College of Medicine, where she is also part of the faculty for the Stem Cells and Regenerative Medicine Center, the Center for Cell and Gene Therapy, and the graduate programs in Immunology, Developmental Biology, and Translational Biology and Molecular Medicine. A native Houstonian, Dr. King received her BA in Biochemical Sciences from Harvard University and her MD and PhD degrees from Washington University in St. Louis. She completed her residency, chief residency, and fellowship training in Pediatric Infectious Diseases at Baylor College of Medicine. She is now the Associate Vice Chair for Research in the Department of Pediatrics and the Co-Director of the Medical Scientist Training Program at BCM.
The long-term goal of Dr. King’s research is to alleviate deaths from infectious diseases. Given that severe infections are frequently related to weaknesses in the immune system, Dr. King’s research focuses on the molecular mechanisms by which inflammation affects blood and immune cell production by hematopoietic stem cells in the bone marrow. Dr. King has been the recipient of a NIH K08 mentored physician scientist training award, the March of Dimes Basil O’Connor Starter Scholar Award, the Aplastic Anemia and MDS International Foundation Liviya Anderson Award, the Presidential Early Career Award for Scientists and Engineers (PECASE), and the DeBakey Research Award. She is a member of the American Society for Clinical Investigation and the American Pediatric Society. Her research has been published in highly regarded journals such as Cell Stem Cell, Cell Reports, and Blood.
Current projects in the lab include:
Impact of Infection and Inflammation on Hematopoiesis
We are studying how infections affect the quiescence, epigenetic programming, and differentiation of hematopoietic stem cells and their progeny. Our studies may lead to ways to prevent bone marrow suppression after chronic infections or enhance trained immunity. Funding to support this project: NIH R35, 2021-2028
The Role of Infection and Inflammation in Clonal Hematopoiesis
We are studying how the differential responses of hematopoietic stem cells to inflammation contribute to clonal competition and emergence of leukemia. These studies provide a mechanistic understanding of how infections affect cancer risk. Funding to support this project: NIH P01, 2022-2027
Microbiota-dependent Regulation of Primitive Hematopoiesis
An adverse side effect of antibiotics is that they may suppress blood and immune cell production by the bone marrow. We demonstrated that these adverse effects of antibiotics are due to disruption of the intestinal microbiome and associated type I interferon signaling. Our current work will define the molecular pathways through which the microbiome signals to support normal blood production. Funding to supporting this project: NIH R01 (co-I), 2018-2023
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KING, KATHERINE